产品编号：G33340
产品类型：小分子化合物
英文名称：GSK484 hydrochloride
中文名称：GSK484盐酸盐
英文别名：GTPL8577; AOB6992
CAS：1652591-81-5
分子式：C27H30ClN5O3
分子量：510.03
InChi Key：InChIKey=MULKOGJHUZTANI-ADMBKAPUSA-N
Smiles：C(N1C(=CC=2C1=CC=CC2)C=3N(C)C=4C(N3)=CC(C(=O)N5C[C@H](N)[C@H](O)CC5)=CC4OC)C6CC6.Cl
外观：固体粉末
作用通路：Chromatin/Epigenetic
作用靶点：PAD
溶解性：Soluble in DMSO、Ethanol、H2O
纯度：0.99
保存条件：-20℃
注意事项：
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料：
GSK484 hydrochloride (GTPL8577) is a reversible peptidyl-arginine deiminase 4 (PAD4) inhibitor. It binds to PAD4 with high affinity, with IC50 of 250 and 50 nM in the presence and absence of 2 mM calcium, respectively. GSK484 promotes the radiosensitivity of colorectal cancer (CRC) and inhibits NET formation in vitro and in vivo.
