中文名称:瑞来巴坦
英文名称:Relebactam
别名: MK-7655;Relebactam anhydrous;(-)-Relebactam anhydrous
CAS No:1174018-99-5
分子式:C12H20N4O6S 分子量:348.38
Description：
Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes. Target: beta-lactamase Imipenem with Relebactam is active against Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp., including K. pneumoniae carbapenemase (KPC)-producing isolates. The combination of Imipenem with Relebactam demonstrated activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa. The imipenem MIC50 and MIC90 values for the ESBL-producing isolates were 0.25 and 0.5 μg/ml, respectively; with the addition of Relebactam, the corresponding values were 0.25 and 0.25 μg/ml. Five isolates harbored blaKPC. For these 5 isolates, the imipenem MICs ranged from 0.5 to >32 μg/ml. With the addition of Relebactam, the MICs decreased to
0.12 to 0.5 μg/ml.[1] Relebactam inhibits most class A and class C β-lactamases, with selected inhibition of class D enzymes by avibactam. β-Lactamase inhibitors (BLIs) have played an important role in combatting β-lactam resistance in Gram-negative bacteria, but their effectiveness has diminished with the evolution of
diverse and deleterious varieties of β-lactamases.
储液制备及储存：
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Solvent&Solubility
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In Vitro:
H2O : 72 mg/mL (206.67 mM; Need ultrasonic and warming)
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Preparing Stock Solutions
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Solvent Mass
Concentration
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1 mg
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5 mg
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10 mg
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1 mM
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2.8704 mL
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14.3521 mL
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28.7043 mL
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5 mM
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0.5741 mL
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2.8704 mL
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5.7409 mL
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10 mM
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0.2870 mL
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1.4352 mL
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2.8704 mL
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*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。 -80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
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